Treating Coccidia With 12.5% Sulfadimethoxine and Dyne in Dogs and Puppies – Dosage Chart and Instructions


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Treating Coccidia With 12.5% Sulfadimethoxine and Dyne – Dosage Instructions

12.5% Sulfadimethoxine is an antibiotic drug used in chickens, turkeys,  cattle and both dogs and cats for the treatment of a number of different bacterial infections, including bronchitis, pneumonia, the infection of a wound or physical injury, salmonilla, and outbreaks of coccidiosis.

This page is about how to treat dogs and puppies for Coccidia or Coccidiosis ONLY.  If your puppy or dog has bronchial symptoms of pneumonia,  Please see your Vet. 

Coccidia symptoms in young dogs include diarrhea which can include mucus and blood, poor appetite, vomiting, and dehydration.

Adult dogs can become somewhat immune and remain asymptomatic but still capable of spreading the disease so, ALL DOGS on the property should be treated whether they have symptoms or not. 

This page will tell you how you can treat puppies and dogs with 12.5% Sulfadimethoxine by mixing it with Dyne so that puppies don’t spit it back out and the dosage needed once mixed. 

Do not give to cats or kittens with Dyne

**There is more info on this treatment on the Beagle Unlimited website.




You can still use this medication without the Dyne,  however it’s pretty nasty tasting so to make it more palatable I like to use the Dyne mixed in. 

Dyne is a sweet tasting,  high calorie fluid supplement which by itself is also helpful for puppies with diarrhea. It is very thick alone but once mixed with the Sulfa becomes a milky like mixture.  

If you don’t have Dyne or don’t have time to order it right away,  you can use: water, gravy or chicken/beef broth as well. 

Also make sure to provide lots of fresh water 24 hours a day. 

The ratio should be 4oz {12.5% Sulfadimethoxine} mixed with 6oz of your other fluid. 

That is because you are cutting down the 12.5% solution to match the 5% solution.

  1. To make the math easier, I checked how much volume needed to make 10 ounces
  2. Divide 5 by 12.5 = 0.4
  3. Multiply the total volume by the number you got in step 1, in this case I chose a total volume of 10 ounces: 10 x 0.4 = 4 ounces of 12.5% medication
  4. From the total volume (10 ounces) subtract the volume of medication (4 ounces) to find out how much Dyne to use = 6 ounces

The correct mix is:
4oz {12.5% sulfadimethoxine) to 6oz Dyne

The dosage is:

  • Day 1: 5ml per 10lb body weight
  • Day 2-10: 2.5ml per 10lb body weight

*Make sure to get a correct weight for each dog and/or puppy before dosing. 


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Coccidia spreads from one animal to another by contact with infected feces which can become stuck to their fur so make sure to clean your kennels/crates and/or puppy enclosures with a bleach and water solution.

Wash each puppy and Mama as well.  Pay close attention to the private areas and the back of their legs where feces 💩 tends to stick when they have diarrhea.  You may also want to give each one a sanitary clip to ensure all the feces are cleaned off the coat as well. 

Clear your grass/yard of all feces every day during and after treatment. 

Most disinfectants do not work well against coccidia; incineration of the feces, and steam cleaning, immersion in boiling water, or a 10% ammonia solution are the best methods to kill coccidia. Coccidia can withstand freezing. 


Q: How many days is the treatment? 

Treatments is 7-10/days but you can do an extra 3-4 days for tougher cases.

Q: How many days until symptoms subside? 

A: I have found it starts to work after a few days but for severe cases may take up to 3 wks to completely clear up.  They may still get a positive fecal even after symptoms have cleared up. 

The symptoms for Coccidia and Giardia are very similar so a fecal test is going to be the most helpful tool to know which treatment you need to use. The best treatment for Giardia I have found is Fenbendazole,  brand names are Safeguard and Panacur.

See my post on treating Giardia with Safeguard by clicking here. 

Q:  Some vet websites now sell “sulfamethoxine” and they said it was the same thing as “sulfadimethoxine”. Is that true?

A: No, This is NOT true , they are not the same drug.

Q: How long is the Dyne – Sulfa mixture good for? 

Mix up only what you’ll use for approximately 3 days and then make another batch as needed. 

Refrigerate after mixing. The mixture will begin to seperate,  so make sure to mix very well. 

Expiration date for sulfadimethoxine and Dyne are also printed on the containers but that date doesn’t always mean after opening,  mixing or cross contaminating..  so I like to play it safe. 

Q: What is the dosage just straight, without the Dyne mixed in? 

A: Sulfadimethoxine 12.5% solution contains 3.75 grams per ounce. This is 3750 mg. per ounce, one ounce = 30 ml , so 1ml of the Sulfadimethoxine 12.5% contains 125mg of the sulfa med.

Dosing without Dyne mixture:

Initial Dose: 25 mg/lb (55 mg/kg) of animal body weight.

Subsequent Daily Doses: 12.5 mg/lb (27.5 mg/kg) of animal body weight. (7-10 days )

You can give the straight 12.5% Sulfadimethoxine in dogs food bowls with a little beef broth or soup to insure bowls are licked clean. Of course, all dogs and puppies must be separated at feeding to make sure a full daily dose is consumed.

You can also give orally with dosing syringe.

You can buy 12.5% Sulfadimethoxine over the counter on


Dyne High Calorie Liquid Supplement – 1 Gallon on Amazon! 

Dyne High Calorie Liquid for Dogs, 1 Gallon

Click above for the Gallon size or you can get the Dyne – 32 Ounce Bottle on Amazon Here!

12.5% Sulfadimethoxine – Generic Albon on

Di-Methox 12.5% Sulfadimethoxine Solution - Treating Coccidia in Puppies and Dogs - Generic Albon

Buy 12.5% Sulfadimethoxine Solution on Valley Vet

Coccidia in Dogs and Cats

Coccidia are parasites that are often misunderstood. After the first exposure, Coccidian parasites are always present in the animal’s intestines, and they’re just waiting to take advantage of any digestive upset. It is rarely the initial cause of the diarrhea, but once diarrhea starts, the Coccidia will grow to large numbers to keep the diarrhea going.

Coccidia are spread through feces, and younger animals are more susceptible to the disease because of their underdeveloped immune systems. Coccidia are a major issue for babies under eight weeks old and can even kill them.

Puppies can be exposed to coccidia but still remain symptom free and then after they go home due to the stress of travel,  a new home etc the stress can trigger symptoms in susceptible animals.

Symptoms in young dogs include diarrhea with mucus and blood, poor appetite, vomiting, and dehydration. Exposed and infected adults may remain symptom free.  All dogs on the property should be treated whether they have symptoms or not. 

Transmission of Coccidia

Puppies are born with a sterile gut, and their mother seeds their gut with good bacteria during cleaning and care. However, puppies are often introduced to Coccidia through their mothers’ infected feces. Coccidia can be spread from puppies to kittens and vice versa. The goal is to keep the puppy’s exposure to a minimum number.

There are a variety of products you can use for both treatment and prevention, but the goal is to keep the numbers so low in the kennel that you rarely need to treat.

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